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Life Sciences Food and beverage

Single-Use Bioreactors Nucléo™

Nucleo

Model

Single-Use Bioreactors Nucléo™

Technical sheet Contact

Model :

NucleoTM, the next generation range of Single Use Bioreactor, offers a complete turnkey solution to cell culturists as an alternative to conventional SIP Bioreactors to shorten timelines, reduce budget and increase flexibility.

Applications :

- User benefits -

  • perfectly adapted to the cultivation of suspended and adherent cells at very high densities and compatible with batch, fed-batch and perfusion processes
  • cube-shaped design incorporating a patented mixing paddle with a dynamic sparger device

- superior mixing capabilities with drastically reduced shear stress

- superior oxygenation and high KLa with minimum gas volume

  • customizable system (modular or fully integrated configuration)
  • five standard interchangeable bags, from 20 to 1000 L w/v plus custom bags on request
  • single-use bag technology

- integrity™ TK8 film with validation package - All contact surfaces of same ATMI medical grade ULDPE material

- no need for CIP/SIP

- minimise all cross contamination risks

  • Neptune™ Control system with intuitive graphical user interface and advanced functionalities (profile, calculation, off-line data and strategy modules) suitable for Research & Development or production
  • Micro-PLC – PC based Control technology ensuring robustness and reliability to the system
  • Software developed from non-proprietary platforms (WinCC, iFix, InTouch) complying with GMP requirements (21 CFR PART 11) and GAMP 5
  • remote supervision and maintenance of multiple bioreactors via Ethernet™ network
  • optional test and documentation package for GLP / GMP environment (FS, HDS, SDS, FAT / SAT Protocols), supporting qualification activities.

Practical case

Nucleo

Description :

Single-Use Bioreactors.

Applications :

Cell cultivation applications, from R&D to industrial scale, for the production of vaccines, therapeutic proteins, monoclonal antibodies, etc.

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